Sex Differences in Resting State Neural Networks of Nicotine-Dependent Cigarette Smokers

Females > Males

Axial Sections . Sagittal Sections . Coronal Sections
Back to Home
How to use this site

Select one of the three views above to begin. The images will be displayed in a table on the left, with a slideshow panel on the right.

Clicking on an image on the left will set the slideshow to that image.

The slideshow can be used to manually or automatically flip through the images in order.

Abstract

AUTHORS: Wetherill RR, Jagannathan K, Shin J, Franklin TR.


ABSTRACT:

Although several sex differences in nicotine dependence have been identified, the neural mechanisms underlying these sex differences are not clear. The present study examines sex differences in resting-state brain activity using an arterial spin labeling (ASL) perfusion imaging technique. Fifty-one (31 males) sated nicotine-dependent cigarette smokers underwent perfusion functional magnetic resonance imaging during the resting state. Using functionally defined hippocampus/amygdala (HIP/AMY) seed regions, we observed sex differences in correlation strength between the HIP/AMY and the bilateral anterior insula, rostral anterior cingulate cortex, and inferior parietal lobule with females showing stronger functional coupling than males. This pattern of synchronous variations in dynamic cerebral blood flow is consistent with recent models of nicotine dependence, and as such, our findings provide a novel perspective on the neural mechanisms that may contribute to sex differences in nicotine dependence.